We would like to extend a huge thank you to all the teams who participated in the 2021 Division II College Classic!
| Away | Home | Time | |
| Dates: Mar 4 | Northwood University – 1 | Tiffin University – 8 | 10:00 AM |
| Site: Historic Fleming Stadium | Cedarville University – 8 | Ashland University – 11 | 1:30 PM |
| Format: College Series | Ashland University – 11 | Barton College – 8 | 5:30 PM |
| Date | Away | Home | Time |
| Dates: Mar 5 | Cedarville University – 0 | Northwood University – 1 | 10:00 AM |
| Site: Historic Fleming Stadium | Northwood University – 11 | Cedarville University – 4 | DH |
| Format: College Series | Grand Valley State University – 2 | Kentucky Wesleyan College – 7 | 4:00 PM |
| Kentucky Wesleyan College – 6 | Grand Valley State University – 7 | DH | |
| Date | Away | Home | Time |
| Dates: Mar 5 | Ashland University – 6 | Tiffin University – 22 | 12:00 PM |
| Site: Barton College (Nixon Field) | |||
| Date | Away | Home | Time |
| Dates: Mar 6 | Grand Valley State University – 2 | Cedarville University – 10 | 11:00 AM |
| Site: Historic Fleming Stadium | Tiffin University – 6 | Northwood University – 12 | 2:30 PM |
| Format: College Series | Kentucky Wesleyan College – 6 | Ashland University – 1 | 6:30 PM |
| Date | Away | Home | Time |
| Dates: Mar 7 | Grand Valley State University – 9 | Mid-Atlantic Christian University – 1 | 11:00 AM |
| Site: Historic Fleming Stadium | Mid-Atlantic Christian University – 1 | Grand Valley State University – 23 | DH |